I love my Fujifilm XT2 and these are the settings I tend to use most
I Shoot RAW + Fine JPG - set to M (12Mp) size so I get a full 24Mp RAW plus a super clean super sharp 12Mp JPG which is good enough a lot of the time for event work
To avoid Haloing in the JPGs I have sharpness to Minus 2 .... Noise reduction to Minus 3 seems to be a good balance between detail and leathery low NR artifacts - using the 12Mp size on these settings is superb and reminds me of the old Bayer 12Mp X100 and its almost Perfect ultrasharp JPG engine , if I need to crop or more rez, I`ve got the RAW..
I set boost to ON
Smallest single AF point with the full number of points available set in the menus
Choose Film sim depending on shoot / subject ..
For portraits I love the look of Astia with DR200 and +1EV. It brings up the mid tones and preserves the highlights.